One-pot synthesis of quinoline derivatives using choline chloride/tin (II)
chloride deep eutectic solvent as a green catalyst
Dana Shahabi, Hossein Tavakol ⁎
Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran

In thiswork, various quinoline derivatives were prepared efficiently through a one-pot, three component synthesis
using choline chloride/tin(II) chloride (ChCl·2SnCl2) deep eutectic solvent (DES) as a green catalyst. The procedure
is free of using toxic solvents or catalyst and it could be categorized as a greenmethod. In this procedure,
aniline derivatives, aromatic aldehydes and enolizable aldehydes were mixed in the presence of DES that plays
both roles of solvent and the reaction catalyst. Using this methodology, quinoline derivatives were synthesized
simply at 60 °C in 2–3 h with high yields (54–97%). All products were purified by chromatography and recrystallization
in ethanol. The employed DES have been recycled 4 time without important loss of its activity.
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