H. Tavakol and A. Heydari, One-pot reduction of aldimines in LPDE 5M  12^th Iranian seminar of Organic Chemistry, Ahwaz jundi shapour university of medical science, Ahwaz, Iran, 7-9 March 2006

Abstract

Amines are an important class of compounds in synthetic [1] and industrial chemistry [2].  In addition, one of the namely devised methods for preparation of amines and other Nitrogen-containing compounds is Reductive amination [3-5]. In these reactions, amines are produced from reduction of imines or iminium salts that they can obtained from carbonyl compounds and primary or secondary amines. These reactions also can be carried out in one-pot synthesis (in-situ preparation of imines or iminium salt). During the course of our investigations dealing with the use of Lithiumperchlorate in multicomponent reaction starting from aldehydes [6], an attempt was made to utilize Boran complex for one-pot reduction of imines to corresponding amines. In our researches, we succeed at in situ preparation of imines from condensation reaction between amines and aldehydes in high yield, and then reduced them to corresponding amines. Both two steps are carried out in one vessel and in presence of Lithium Perchlorate and Trimethylsilylchloride as a catalyst in Diethyl Ether solution. In scheme 1, we report the common reaction that in all cases, the reactions proceeded smoothly at ambient temperature with various aldehydes and amines and reasonable yield in 2h.