Chemoselective addition of organometallics to oxime ethers
Hossein Tavakol a,*, Saedeh Zakery a, Akbar Heydari b

a Chemistry Department, Science Faculty, Zabol University, Zabol, Iran
b Chemistry Department, Science Faculty, Tarbiat Modares University, Tehran, Iran

Abstract
In this paper, an efficient method for preparation of various substituted hydroxylamines from aldehydes is reported. We first prepare
O-trimethylsilyl oxime ether in 5 Msolution of lithiumperchlorate in diethyl ether (LPDE 5M) from condensation reaction between aldehyde and O-trimethylsilyl hydroxylamine, then add organosilane or organotin nucleophile in the same vessel to preparing the corresponding a-substituted hydroxylamines in one-pot synthesis.  2007 Elsevier B.V. All rights reserved.

Keywords:

Oximes; Organosilane; Chemoselective reactions; Lithiumperchlorate; Multicomponent reaction; Organotin